The Whole View, Season 3, Episode 85: Green Washed, CBD Updates w/ Inesa Ponomariovaite

Stacy updates the science on CBD and talks to Inesa Ponomariovaite about her research on the cannabidiolic acid (CBDa) used in Nesa’s Hemp. They discuss how CBD supports health in our endocannabinoid system and why quality and safety testing matters. We also revisit even more of the science of CBD from a 2020 episode with Sarah Ballantyne, PhD.

Find Nesa’s Hemp:

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Key Takeaways about CBD


  • Inesa grew up in Lithuania and came to the United States at 21 years old. She had many health challenges and after doing the same things over and over again, starting looking for solutions outside of traditional medicine and pharmaceuticals.
  • After Inesa received a call that her mother had cancer, she wanted to explore every possible option to help her. So this led her down a path where she dedicated nearly two years to the study of CBD. Her research led her to doctors, scientists and patients worldwide. She analyzed industry data and test results for hundreds of CBD products.


A 2021 study noted, “Cannabidiol (CBD) is a primary component in the cannabis plant; however, in recent years, interest in CBD treatments has outpaced scientific research and regulatory advancement resulting in a confusing landscape of misinformation and unsubstantiated health claims.” Then found “CBD-rich treatment has a beneficial impact on pain, anxiety, and depression symptoms as well as overall wellbeing only for patients with moderate to severe symptoms; however, no observed effect on mild symptoms.” [source]

  • In living hemp, CBDa is the main phytocannibanoid compound that offers major health benefits to the body, so it’s the parent compound to CBD. The “a” stands for “acid”, as it’s an cannabidiolic acid.
  • CBDa and CBD both interact with the body through the human endocannabinoid system, a regulatory network that alters the release of neurotransmitters in the brain to keep functions in balance.
  • CBDa and other cannabinoids CBGa and THCa have shown effectiveness in supporting a healthy inflammation response and promoting the self-healing process, among a plethora of other health improvements.
  • “It is believed that the endocannabinoid system, which includes G-protein coupled receptors and their endogenous lipid ligands, may be responsible for the therapeutic modulation of oxidative stress in various diseases. In this context, the phytocannabinoid cannabidiol, which was identified several decades ago and may interact with the cannabinoid system, is a promising molecule for pharmacotherapy.” [source]
  • Most commercial extraction processes use temperature extremes and solvents that kill off the CBDa. So Inesa found it incredibly important to ensure the quality of their process, designed to preserve as much of the plant’s natural compounds as possible. An independent medical grade lab tests each batch of Nesa’s Hemp to guarantee consistency.

Revisiting CBD

  • CBD is an abbreviation for the phytochemical cannabidiol, a non-psychoactive component of Cannabis sativa. 
  • The endocannabinoid system is one of the key endogenous systems regulating pain sensation, with modulatory actions at all stages of pain processing pathways. Because it is part of this pain sensory system it is also part of all physiological systems that modulate healing.
  • Furthermore, the endocannabinoid system is involved in a host of homeostatic and physiologic functions, including modulation of pain and inflammation.
  • The way that CBD works in the body is by binding with CB1 and CB2, two main receptors of our endocannabinoid system. In general, CB1 receptors are found in the central nervous system and CB2 receptors are found in the periphery and are found in virtually every tissue in the human body.
  • CBD is something that has the possibility of being an adjunct in many situations that is going to potentially add to how our body is positively responding to all of the other healthy diet and lifestyle things that we are doing.

Studies, References & Products


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Note: Stacy and her guests are not medical professionals. This podcast is for general educational purposes and NOT intended to diagnose, advise, or treat any physical or mental illness. We always recommend you consult a licensed service provider.

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